Yes, 65# is probably enough for most game if you're close enough and place it well. I'm far from an archery expert, but I think the average man is capable of drawing, holding, and shooting a 75# selfbow, much less a compound.
I'd start with the lower range, but there's nothing wrong with finding an adjustable with the range to cover the weight you're comfortable with and on up to the weight you want to be using later. Beyond that:
1. Keep gadgets to a minimum. Same principle as a gun. Gadgets will make you worse, not better, when you start out. If you want to get good really fast, then pin sights are fine. It's probably better to learn to shoot instinctively, but I started with pin sights. They're simple, robust, and hard to break. I wouldn't use a release or spend money on silencers for the string, and you don't need those big balance rods.
2. Pay attention to length on both the bow and the arrows. This can be pretty important, if you aren't average. My family has long ape arms, and we have to be careful about draw lengths.
3. Don't think you need to spend a fortune. Fancy materials, etc. etc.
I'm sure you know this stuff, but that's what I've got to offer. Like I said, I'm no archery expert.