.25 is least useful (not counting funky proprietary stuff).
If you're going for small get the .22. Rounds are cheaper and .22 is respectable for it's size in that even the most elitist gun nuts will have a .22 or four for cheap fun shooting.
If you're looking for something larger then a .22 get a .380. At least the bullet diameter is in the mid caliber range...even if there isn't as much powder behind it. .380 pistols aren't much bigger than .25's and the ammo is pretty much the same price.
If you're going for small get the .22. Rounds are cheaper and .22 is respectable for it's size in that even the most elitist gun nuts will have a .22 or four for cheap fun shooting.
If you're looking for something larger then a .22 get a .380. At least the bullet diameter is in the mid caliber range...even if there isn't as much powder behind it. .380 pistols aren't much bigger than .25's and the ammo is pretty much the same price.