Recently started with Grendel myself. I think it should be pointed out the bullet weight matters. CFE223 is too slow burn rate for most Grendel loads. Hodgdon will not list it for Grendel at all. People that do have good reports with CFE223 tend to be loading the heaviest bullets that will fit, and no less than 123gr. That makes the versatility of that powder for Grendel very limited. Lighter bullets may be significantly less costly to shoot. I'm shooting 90 gr. Speer TNT to start with because the bullet cost is half that of Hornady 123 gr. I plan to hunt with 100 gr. bullets. I don't think CFE223 would work well with the 90 or 100 gr. bullets that are popular for Grendel.
I'm just getting into this, but from what I've learned, I'd suggest to look at H335, IMR8208, or Reloader 15. I haven't used it yet, but 8208 has the best reports for wide nodes of for accuracy, temperature insensitivity and overall forgiveness. From what I've read, it sounds hard to go wrong with that powder for Grendel. I'm using H335, but I've only shot 40 rounds of it so far.