Aside from something changing with your shooting fundamentals, wind (which you say isn't an issue), load (which I don't get, not transsonic at 300 and the bullet will get more stable as it slows down), I'm going to go with... scope parallax... which can actually be a function of the shooting fundamentals - your shooting position and location of your cheek weld, and therefore the position of the eye behind the scope is different from shot to shot, changing what should be a 3-4" group at 300 into a 8" group.
It has happened to me.