Two thousand full throttle rounds will put some serious wear on a 19/66. But not only light bullets, the heavy recoil of any magnum load will torque the frame and eventually warp it. The Rugers avoided this by designing their guns with solid frames. Recoil is evenly distributed throughout. While the Smiths were falling apart, locking up ang going out of time, Rugers were holding up remarkably well. Skeeter Skelton said he knew of three Security-Sixes, each which had digested over 30,000 rounds! One was slightly out of time, but was fully fuctional.
C.E. Harris said he wore out a K-framed 19 by firing 2,000 hot magnum loads. After repairing it once, he put another couple thousand magnum rounds through it before frame warping finally damaged the gun beyond repair. So think about 5,000 rounds as a lifespan with hot loads.
If you shoot .38s and +Ps in them, they should last forever. Then an occasional magnum cylinder or two won't make a difference. Although I've seen cracked forcing cones in 66/65 revovers, stainless steel resists gas cutting and blasts better than blued carbon steel.
I wish Ruger would reintroduce their Security- and Speed-Six models. I don't like the heavier models, their stubby grip shafts, lock-ups and balance. They're certainly no improvement over the earlier models.