From what I have read, it depends more on the projectile's hardness (high % of tin, or solid copper sabot) than weight.
As an example of comparative power, a 325 grain muzzleload over 150 grains of powder departs at 1,723 FPS. The .45-70 Gov't, in 330 Gr lead projectile, loaded for lever action rifles, achieves 1,734 FPS. That round would certainly not be doubted as sufficient. Ergo, I say yes.
Doc2005