Typically, in any caliber, the lighter the projectile, the slower the twist and the heavier the projectile, the faster the twist.
Take a 1 pound rock and a 1/2 pound rock and throw each one. The lighter rock takes more effort to travel the same distance as the 1 pound rock. Once an object gets moving, it travels on its own mass.
Folks that have standard AR-15's shooting 55 to 60 grain bullets will usually have a barrel twist of 1:12". Competition shooters using Sierra 77 grain Matchking bullets to reach the 600 yard target frame, accurately, will have a barrel twist of 1:7".
The traditional T/C rifles came standard with a 1:48" twist, which was a compromise twist to use both round ball and Maxi-Ball/Maxi-Hunter conical balls.
T/C had drop-in barrels made by Green Mountain for round balls that were 1:66" twist. When the inline rifles were introduced, they, typically had barrel twist around 1:32" twist. Shorter barrels like the T/C Treehawk (camo W. M. C.) with 21" barrels had a 1:20" twist to stabilize conical bullets with and without sabots.
A Lyman Great Plains rifle in .50 or .54 caliber have been dropping elk since the seventies with a round ball. The late John Baird's magazine, The "Buckskin Report" would have a "photo page" in every issue, showing everything from whitetail deer to "buff". The only requirement for publication was the game animal had to be taken with a round ball. I can honestly say over the decades of his publication, hundreds of photos showed big game taken with that little projectile.
For anyone who wants to use a "compromise" projectile in a .50 or .54, Buffalo Bullet Company offered a "ball-et". Instead of a 180 grain round ball, the ball-et is 220 grains, but I can't speak for its accuracy. One must do his homework to find out. It's called testing out loads.
Accuracy is and always will be 99% mental concentration from "the nut behind the trigger".