I've used that particular Lee with right under 40 grains of H4895. Gets it going about 1500 fps, trap door level load. Kills paper just fine, im sure it would drop a deer as you've described just as well.
I like the 405's better. Used IMR4064 mostly with those. These are the only ones I've hunted with. Its overkill for deer around here even going slow. Have found good loads with other powders too like H322, H335, Varget and Benchmark. Could be the design but the 405's feel better and are generally more accurate for me, or easier to find an accurate load.