It's a bad idea in general. For many reasons, it's just way safer to empty the powder measure back into the original container when you end for the day. Yeah, I had a couple occasions when I got interrupted unexpectedly and left some powder sit in one of my powder measures. No harm in those cases. But a few people have reported the plastic finish was left cloudy after just one night. Different powders seem to be worse than others about it. But if it's at all possible, go ahead and empty the powder measure when you're done for the day.