New Service 1917 Army repro from Colt would be cool, in stainless, though, but avilable with a black finish.. say with two cylinders 45 acp AND 45 Colt. better yet 44 magnum.
Still, a .357 version would be very nice too.
Would still like to see the DS and Magnum Carry back in the line up, though I've already got a Magnum Carry.
From SW I'd like 6 shot 2 inch unported 45acp revolver. No good reason, just think it would be cool.
Still think Uberti/Pietta/etc. could make a nice repro 1878 New Frontier or 1877 Lightning/Thunderer DA revolver. 38 special and .45 Colt (since no one shoots the .41 Colt anymore) Uberti has made some very NICE replicas, so why not these too?