I have the 10/22 Takedown "Tactical" model (flash hider/threaded barrel).
With mine (might be the exception), if I follow Ruger's directions in tensioning the barrel plus add another couple of clicks of tension on the knurled nut, it will shoot dime sized groups using Wolf ammo all day long and with a small Barska red-dot on it, if I follow the directions plus add the couple of extra clicks of tension, it returns to zero over quite a few cycles of takedown and re-assembly.
I've filled the pockets on that super nice case you get with the Takedown model works perfectly if you fill the pockets with useful stuff.
I put a couple of full BX 25 mags plus another 6 boxes (300 rounds) of ammo in the bottom pocket and in the top pocket, I put a couple Space Blankets & aluminized Tyvek "Cocoon" brand sleeping bags along with some treated cotton tinder & several magnesium/flint fire starters. Also in there is a tube of Neo-Sporin antiseptic cream and some different sized adhesive bandages and I topped everything off with a Leatherman multi-tool. Outside, hung on one of the "D" rings is an aluminum rod wrapped with 50 feet of para-cord. On one of the "Molle" type straps on the bottom pocket, I've hung a Swedish "Mora" knife that can even be made into a spear using a straight stick & some of the para-cord.
This all gets thrown in back seat or trunk of the car whenever my wife and I travel very far from home. We also throw an over the shoulder pack containing a couple days worth of MRE's and a Katadyn water filter. There is always at least a case of bottled water in the trunk that gets swapped out periodically so the Katadyn filter is on hand if that supply runs out.
In the picture, I left the two pockets unzipped to give an idea how they are stuffed. The whole thing weighs in around 12 pounds as you see it and the padded carrying strap that comes with the Ruger makes it quite comfortable (even at my age 71) to carry.
Jim