I have been loading for and shooting the 22-250, .243, and the .270 win, and all have been fantastic shooters. I've loaded for multiple different one's in in each chambering also, and they all have been great performers.
The only thing I don't care for is the triggers. I have never been pleased with any trigger in a production rifle, so that's not unusual. But what I specifically don't like about the Ruger trigger, is you can't fine tune adjust it like you can a Rem or Savage, you have to replace it. The best I could get out of one was about 4 lbs.. I don't care who you are, 4 lbs. is horribly unacceptable. I saw a You Tube video on how to clip partial coils off the spring to get them down to a more realistic functional shooting weight, but it's just much easier, not to mention safer to just drop a better trigger in them and be done with it. A Timney is only $120 or so, which I think is a small price to pay for a production rifle that can be made to shoot sub MOA groups with the right load.
The stock too leaves a little bit to be desired, but again, I haven't come across very many budget rifles that had a good stock on them. But floating the barrel or shimming the V bedded action are simply little things, and that don't cost anything to do. Although, if one were to add an after market stock and a Timney trigger, I can't see how that would be unreasonable for a rifle that's already a shooter.
GS