Unless you're planning on hiking in bear country, I'd go with the 357. 1) Much cheaper ammo, especially if you reload, 2) Less flash, blast, and recoil, 3) the 357 will most likely do everything you need a handgun to do. Even if I were hiking in bear country, black bear, not grizzly, I'd feel comfortable with my 180 grain XTP's on top of 13.5 grains of 296.
For home defense, target and range use, the 357 is a much better choice.
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