Disclaimer: Like many other pistol manufacturers, Glock does not recommend shooting reloads (including lead reloads), so use reloads in your Glocks at your own risk.
As to shooting lead reloads in Glock barrels, there are several factors to consider -
https://www.thehighroad.org/index.p...ts-and-discussions.778197/page-7#post-9979745
Commercial lead bullets come in different hardness ranging from softer 10 BHN to harder 24 BHN and proper hardness and bullet-to-barrel fit need to be used with sufficient powder charge to properly deform the bullet base to seal the high pressure gas as gas leakage/gas cutting will increase fouling and leading.
Glock barrel / rifling
Sig 1911 barrel on the left with almost no leade and sharp start of rifling, Lone Wolf barrel in the middle with longer leade and less sharp start of rifling, Glock barrel on the right with longer leade and very smooth/rounded start of rifling
As you can see from comparison pictures above, Glock barrels have longer leade and very smooth start of rifling with rounded rifling which allow the lead bullet to slide deeper into the barrel before pressure starts to build which allow more high pressure gas to escape around the bullet.
As
Glen Fryxell details in his ebook Chap 7 , high pressure gas leakage around the bullet blows liquefied lube from the bullet and down the barrel which will leave the bullet with less/no lube and this will increase fouling/leading build up, especially near the chamber end of the barrel.
If high enough powder charge is not used, powder burn may be inefficient and insufficient/inconsistent chamber pressures may not deform the bullet base enough which will allow the bullet to "skid" down the barrel along Glock's smooth rounded rifling and increase fouling/leading build up.
It's been my experience that Glock barrels experience more fouling build up near the chamber and along the rifling than barrels with conventional square land/groove rifling. Depending on the lube used on the bullet, fouling build up may be light/crusty build up to harder build up that's more difficult to remove. Once enough fouling builds up, accuracy will start to decrease. Using 14-18 BHN lead bullets, I have not seen leading in my Glock barrels with different powders and charges but some report leading in Glock barrels.
Regardless of bullet hardness/lube/powder used, I recommend inspecting the barrel around 200-300 rounds for build up (do it more often if you detect more fouling) and clean as necessary as if fouling is allowed to build up, you'll essentially end up with a smooth bore barrel with reduced bore which will increase chamber pressure.