A 250 grain at 700 to 750 ft/sec is the same as the .45 Colt load the US Government used for military Colt 1873 single-action guns after finding that the full-power load was hard on both guns and soldiers. When the .45 Colt was re-adopted for units in the Philippines for use in the Colt 1902 double-action (derived from the old 1878,) and Colt Army Model 1909 double-action (based on the New Service,) they fired a 255 grain conical at 725 ft/sec.
So a 250 grain bullet at 700 ft/sec is okay for defensive purposes. At the sorts of ranges you'd be shooting a Judge, it'll drill nice .45 caliber holes in people. The problem is that it's a hard lead bullet with a lot of momentum behind it. About as much as 230 grain .45 ACP hardball. It has the potential to over-penetrate. For that reason, it isn't quite as desirable for modern self-defense as a decent hollow-point.
A decent expanding .45 Colt round is the old Federal 225 grain lead hollow-point, or a 250 grain Speer Gold-Dot, which moves a bit quicker and expands reliably.