I went through the process of choosing a new .45 last fall (up to $1200), and after handling and firing most of the .45 available, I bought the Ruger KP345DPR.
I'm normally a 1911 man, but for CC I prefer the first round double action rather than carrying cocked and locked. Yes, I know it is safe, but I've always been a bit uncomfortable with it.
The P345 is about the same size and weight as a Colt Light Weight Commander, an excellent gun that I carried for many years, but with the polymer frame and stainless slide it is much more corrosion resistant. I have the 'decock only' model, where the safety lever on the slide drops the hammer and returns to the ready position. This is just as safe as a revolver; a long pull on the trigger fires the first round, and then it functions the same as any regular semi-auto.
That initial double action pull is surprisingly smooth after the first 100 rounds or so. I can shoot very nearly as tight a group double action as in normal single action shooting. The P345's double action triggering is better than many of the big name double actions revolvers I have owned or shot. The transition from the first double action shot to the following single action is something you would be quite used to after a couple of boxes worth of range work.
The gun will feed anything that passes for 45ACP, even empty cases. Accuracy is actually slightly better than the LW Commanders I have owned.
Back in the 70's when I was customizing the available 1911's, I wrote out a list of features I wanted in my 'wish' gun. The P345 fits that list except it is not as accurate as a Gold Cup.
With concealed carry in mind, the gun has been steamlined. All controls and the sights are low profile and designed for a snag-free draw. I usually fire 230g +P ammo since I use this gun both for SD and in the field where shots could be longish and the target a bear or a hog with bad intent. This gun, probably due to the polymer frame, seems to suck up the recoil.
If in spite of all this, if you do not choose a Ruger P345, then go with the Witness!