Former full time LE firearms instructor, with a LT who said I could shoot all the ammo we had, he'd just order more. Challenge accepted.
From December 2012 till our transition in late 2016 I was issued a S&W M&P .40. It was my range gun/teaching gun. Prior to teaching a new class I would routinely put down 250-500 rounds a day for a month or so (yes I once shoot 10,000 rounds in a month, I checked my ammo check out logs to verify this) getting things sorted out as far as drill times, etc. On off weeks, I would still routinely shoot around 100 rounds a day, so I'd average about 500 rounds a week. Rough back of the envelope math, I shot between 100,000 and 200,000 (as a guess I'd say a bit above 150,000) rounds in the 4 years I had that pistol. It was still a serviceable pistol, but comparing to a NIB pistol you could definitely feel the wear and tear. Another year or so and I'd imagine I'd have seen the frame start to delaminate around the rails, or possibly crack in some of the higher stress areas. As far as parts replacements the only parts that were not replaced were the slide and frame. In that 4 year period all other internals including the barrel were replaced at least once (I think I went through 12 slide releases).
-Jenrick