I shoot several thousand full-power .44 mag or .45 Colt Ruger loads a year. Usually 100-150 in a range session. I suppose that puts me somewhere as shooting more big magnums than many people but much less than some folks out there. I also don't have or shoot anything bigger than that.
A 5.5" or 7.5" Ruger Bisley is the darling that I can go the longest with. The subtleties in the grip panels make more difference than the extra length and weight as I just swapped them between guns. With the grips I favor, 150rds isn't even hard and no blisters or hot spots.
For DAs, I have a 6.5" 29-6 and a 4.25" 69. The 69 is an awesome gun. Great woods carry piece. The cyclinder is a tad shorter than the 29/629, but it certainly not weaker as far as I can tell. When I work up a load, my 29 starts getting sticky extraction before the 69. I suspect the 5-shot cylinder and offset bolt notches play a part.
For the DA Smiths, I rely on the Tamer grips by Hogue to make them comfortable. Hard grips or unpadded rubber on the Smiths are much less comfortable to me than wood grips on a Bisley frame. While it helps with stinging the palm, the Hogue rubber also grabs the skin and causes blisters faster.
For me, if I want double-action capability, I grab a Smith but otherwise, the Bisleys are more comfortable for a range day or dedicated target practice.
For what it is worth, I had a regular Redhawk and hated it. Trigger was garbage, it wasn't accurate, and I never could find comfortable grips for it. It eventually broke and had to go back to the factory several times and Ruger eventually traded me a SRH Alaskan for it for free. That is a fun gun, but not very practical.