I will put in another vote for the .327 LCR with .32 S&W rounds instead of the .22. Putting aside the poor stopping power of .22 ammo, there are two additional problems with using rimfire ammo for serious purposes.
I have found quality rimfire ammo has a misfire rate of about 1 per 1,000. While this gives pretty good odds every time you pull the trigger, the odds are significantly worse when you consider firing a whole magazine. And while one per thousand might seem acceptable, it is a far cry from centerfire reliability which can easily be less than one misfire per 100,000 rounds. So due to the greater frequency of misfires, I would not consider a semi-auto .22 pistol where reliability is critical. While everyone should be trained for misfire drills, it is also important to choose equipment that makes them unlikely.
Now with double action revolvers, the drill for a misfire is much simpler, you just pull the trigger again, and fire the next round. This method is simple, reliable, and does not require any extra training. But rimfire ammo has a different problem in revolvers. Rimfire rounds require a significantly harder hammer strike for reliable ignition than centerfire rounds. So in a double action revolver, rimfire rounds require a stronger mainspring, and as a result, a heavier trigger pull. Small revolvers also tend to need heavier triggers than larger revolvers due to the internal leverages. So small rimfire revolvers usually have pretty stiff triggers, and they cannot be improved much with compromising reliability.
So for all of these reasons, I am a fan of small centerfire calibers when someone needs a gun that must be reliable and have minimal recoil. Small rimfire revolvers are fun to shoot, and can be a useful training aid, but I would not want to count on one.