I have sent about a half dozen deer to the freezer with a .357 Ruger Blackhawk. I tend to disagree with some of the ammo selections mentioned here. Deer being a pretty light, thin skinned critter, they are easy to shoot clean through...even with a bow...even lengthwise. If you use a 158-180 gr hardcast bullet, you will shoot a small .357 diameter hole clean through the deer, and the rotten log behind the deer, and 20" down into the forest floor. Oh yeah, you got great penetration all right. So what? I'll tell you what. You have a deer that has a pencil sized hole through it that will easily clot over.I think of it as bow hunting with field points. Even a double-lung shot deer can travel a long ways.
My $.02 says to to a good hollowpoint that shoots poa in your gun. I don't care if it is 110gr or 125gr or 158gr. Win Silvertips, XTP's. whatever shoots good. I'm looking for a .357 entry and the golfball exit. Something like that will put deer in the freezer, and be pretty rough on carjackers too I guess.
That Ruger is a fine gun, I hunt with a .45colt Blackhawk.