Some ideas:
A stiff belt not only supports weapons better when worn, but can maintain its shape well enough when unfastened, that it may well be feasible to simply leave the holstered weapon in place, on the belt, when on the throne. The belt I am wearing at the moment has no label, but is one of several well-recommended belts, with Cobra buckles, I bought some time ago. I am wearing a JM Custom Kydex OWB at 0300, with a G17 inside it. I can sit on the throne with this particular combination; no unholstering required. Other good belts include Instructor Belts, from The Wilderness, and leather belts made by such makers as Milt Sparks, Kramer, and the late G. Wm. Davis.
The Cobra buckle, mentioned in the preceding paragraph, keeps the belt from slipping through the loops.
A weapon carried in an ankle holster requires no special attention when sitting on the throne, and may be A really good idea for those of us whose lives are oriented around the nearest throne room. (I have occasional bouts of I.B.S.) The usual caveats about ankle carry do apply, of course. (For me, ankle carry is usually for a secondary or tertiary weapon, and has been special-occasional since I retired from LEO-ing.
Many shoulder rigs are independent of the belt, and may be really good ideas for those of us whose lives are oriented around the nearest throne room. I do not wear a shoulder rig on a daily basis, due to the hot, humid local climate, but will wear an Andrews Monarch when traveling in air-conditioned vehicles, and on occasion during our brief winters.
A belly band rig, torso/chest band rig, and variations thereof, are normally independent of the pants belt, and can be really good ideas for those of us whose lives are oriented around the nearest throne room.
A well-pocketed handgun can work well when sitting on a throne, IF one pays attention to all the details. The usual tactical caveats about pocket carry do, of course, apply. (Best discussed in a separate thread.)
For those wearing dressier clothing, where a sturdy belt would be out-of-place, well, a tailor can reinforce and deepen pockets, as necessary, to accommodate larger and heavier items. A gun-friendly tailor can alter a suit coat or sport coat to accommodate a weapon worn in a shoulder rig.
Placing a weapon hammock-style, in one’s drawers, makes it less-likely to forget that the weapon is there.
I will end by saying I prefer my first-mentioned option; leaving the weapon in the holster, on a sturdy belt.