As a general purpose, very accurate and rugged .22RF, I don't think you can beat the Ruger Mk series. Sure, their triggers aren't the best but there are many after-market options to improve that, and then they can even hold their own on most bullseye ranges. The S&W 41 or the older HS models are other good ones; just alot more money for not alot more performance IMHO.
I don't consider the P22 or the Skeeter to really be pistols at all. Just inexpensive copies and look alikes of CF combat firearms.