For a dedicated hunting sixgun wearing optics, the Super Redhawk can't be beat. Unlike most other choices, you get to mount a scope or red dot and keep your irons.
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And they tend to be extremely accurate.
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The Ruger Bisley is a good choice as well but I would treat it like a five-shot .45Colt. Most factory .454 loads as well as most handloading data is at least 10,000psi below maximum and that's where I'd stay. I would go no further than Brian Pearce's "Redhawk only" .45Colt loads that are in the 50,000psi range. Do some tuning and fit some custom grips and you have a very capable sixgun. You could also save up for a used Freedom Arms. I got my Field Grade for the princely sum of $1500 with an auxiliary .45Colt cylinder.
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No offense to the fans but I've tried and just can't warm up to the BFR. There are things about them I don't like and since they can't be converted to a Bisley I'm not going to bother. That said, I think they're very strong, very well made guns that are closer to FA's than Rugers and a real bargain on the current market. I don't like the round tube ejector housing, the screw-on front sight, the shape of the blocky triggerguard or the banana shaped grip frame. Plus they're only available in stainless steel and I've had all of that I can stand.