I agree with everything in this post!22 TCM wouldn't be my first choice for self defense... I prefer .45 acp. But that doesn't mean that 22 TCM isn't a heck of a fun cartridge to shoot! ...and it would probably get the job done on a pinch.... with proper shot placement.
22 TCM pretty much has no recoil and the recoil springs are very mellow so it might be a very good choice for someone with arthritis or other hand strength issues. Shooting 22 TCM makes even a delayed blowback 380 feel like a recoil beast.