"Manhunter" 1986 was adopted from the Thomas Harris novel "Red Dragon" prequel to "Silence of the Lambs". The remake movie "Red Dragon" was truer to the novel, but I think the style of "Manhunter" better matches the bleak devastated soul of the FBI agent who has gazed too long into the abyss opening the depths of his soul to chaos. Friedrich Nietzsche vibe to this movie. When FBI agent Will Graham goes forth to do battle with monsters (wondering if he is becoming one himself), his weapon of choice is a Charter Arms .44 Special Bulldog, magnaported barrel, fat grips, loaded with Glaser safety slugs. The serial killer Francis Dollarhyde uses some kind of pistol with silencer on his killing runs. For home defense he has a 12ga pump, extended magazine, pistol grip, with a muzzle attachment. Feds and local LE following Graham carried 12ga 870 riot guns and ARs.
If surprise home invaded I would have at hand as designated home defense a .38 Rossi revolver and a 12ga pistol grip pump 19" barreled 00 buck. If time to prepare, I would go with my .40 H&K USP and M1 Carbine with Win RN SP ammo. These are guns I've fired at range and in field and have confidence they will work as expected. Not maybe the best or something a professional would chose, but guns I know and trust.