I make knives so I've done a littler research on what people like.
Assuming your main thing is white tail sized stuff.
1. Drop point and Clip Point blade shapes are the most popular. Just long enough that if you choke up your grip you can cover the back edge of the blade and protect the point with your index finger. Has to have some curve/belly to it also.
2. Handle should be something that offers a good grip when its wet/bloody and should be easy to clean. Because of that I like handle SHAPE that offers a good grip, and avoid coarse finishes or checkering because they are too hard to clean. Micarta is probably the easiest to take care of and is very easy to work with. Stabilized wood, or exotic hardwoods with a proper finish work too. The main thing is a shape that fits in your hand and doesn't go anywhere.
3. Blade steel is subjective. Some folks swear by carbon steel. Others want a good stainless, and debate whether you have to have S30V, ATS34, BG42 etc. I personally work with 440C because I can heat treat it myself and it offers a great balance of ease of sharpening and edge holding. Its also very tough, you won't mess the blade up if you get into some bone.
4. The sheath should be sturdy and offer a carry method that will keep you from getting cut if you fall or anything. Last thing you want to do is fall out of your tree stand or over a log and have the knife go right through the bottom of the sheath and into you. Kydex is popular for that, and its easy to clean. A well made leather sheath is good too.
Here's what I've come up with and have gotten some positive feedback on it. I used one to skin some racoons (just the tails actually, keepin score
) last summer and like it pretty well.