Well like I said then, either one will effectively put down a deer with little problem. Now granted, as RC pointed out, you will increase your effective range a LITTLE with the 165 but in reality, where that range difference is a factor, is well beyond what any ethical hunter should be taking a shot in the first place. From 400 to 0 yards, the difference is pretty much moot. As long as they are accurate out of your barrel, then the main concern should be placement and bullet construction.