Hi jimmyraythomason: Believe me, I know caliber doesn't guarantee a DRT situation, but I know shot placement makes a big difference and jmho a larger caliber, without getting into sizes that turn deer into instant sausage, decreases the chances of having to chase a wounded animal all over creation, as long as I do my part. Few things can make a hunter feel worse than losing a wounded animal.
Of the 4 deer my friends and I took during the last year, all were DRT. The first 3 fell to 30.06, the last one to an SKS.
None of these shots was more than about 80 yds, not so much because we can't hit anything farther away, but because the terrain where I live is very rocky and brushy with lots of trees, hills and ravines. It's not very common to even see a deer much farther away than that, let alone get a clear shot at it.