I've thought about trying this for IDPA--to shoot a moonclipped 357 in ESR, just for kicks. I think I'd start with 158 gr plated RN bullets (rainier or berrys) and between 5 and 6 grains of Unique and walk it up, watching for problems. I expect you'd get there around 6.5.
That assumes you've got a good .357 revolver, known, quality brass, a chronograph, and experience making, shooting and monitoring high-pressure loads. If you don't have ALL those things, then forget it.