I've reloaded with Clays and Trailboss. I didn't like Trailboss at all and used only one can. I've bought Clays by the 8 pouind jug and used it in 38 Special, 45 Colt, and 12 Gauge Shotshells. If you use a single stage press there is no reason to be concerned if you use the ordinary and reasonable safety precautions, and why wouldn't anyone do that? I used a Dillon 550B and never had any problems, but I was careful and payed attention to what I was doing. I used a small light over the top of my press so checking the powder level was easy. Trailboss powder seemed to be dirty and not all of the powder burned, leaving an unburned residue behind. Other people in our group of shooters used it and had the same results, some continued to use it and others changed to something else. I liked Clays and feel it is a versatile powder, worth considering, I still use it and use it in a 45 ACP as well as those mentioned above..