If there is a fundamental difference in reliability, there must also be a fundamental difference in some intrinsic trait of the two platforms. Can we identify such a difference?
Both types are made on the same tools, of the same materials, using the same general process, so it isn't an issue derived from those things. Both have moving parts, bearing surfaces, metal sliding over metal, etc., so again, it isn't one of those.
If I was called upon to identify the fundamental difference between these systems, I would point to the source of motive power.
The revolver uses animal muscle tissue to power the mechanisms that advance a new cartridge into battery, cock the firing mechanism, release the hammer, etc..
The semi-automatic pistol uses a hybrid system with animal muscle tissue providing some of the power, while energy from the propellant is extracted to power other operations. The exact balance varies depending on starting state, but if we start from a loaded firearm, muscle is used to release the firing mechanism, and may be used to partially (striker fired) or completely (hammer guns) power the firing mechanism. Then propellant energy is used to extract and eject the old round, chamber a new round, and potentially store energy in the firing mechanism.
But that's just me. What fundamental differences do you think are the root cause of such a difference, assuming it exists?
FWIW my experience is that revolvers and semis both have noob traps and an unpracticed user can dig themselves a hole with either one. My favorite is revolvers getting cartridges trapped under the extractor. It is totally preventable user error that an experienced shooter will probably not even acknowledge is a legitimate problem, but I've seen noobs do it to themselves.