I moved back to the old home town of Austintatious in 1963, and among other needs I figured a deer rifle would be a Good Thing. I ran across a Sears&Sawbuck .270 for $70, and stuck a Weaver K4 on it. Got back into reloading.
I killed several deer with the Remington 130-grain Bronze Point, ahead of a slightly compressed load of the old 4831. Easy loading: Fill the case, tap it, scrape across the mouth and then seat the bullet. Not quite a max load.
My billfold improved and I got my present '06 and a little Sako Forester carbine in .243. I've collected a bit over 20 deer with each.
With the .243, I've almost exclusively used Sierra's 85-grain HPBT, and mostly taken neck shots inside of 200 yards. Those deer dressed out most usually at 120 pounds or less. I wouldn't use the .243 on mulies. That bullet is on the nasty side for a poor old coyote, spreading innards across a half-acre or so.
I'd say the .270 is a more all-around cartridge than the .243, unless you're a skilled enough hunter to get pretty close to larger deer. I wouldn't select one for prairie dog shooting, but that's purely a recoil issue--and makes my shoulder hurt, just thinking about turning loose a hundred rounds or more in a day.
Art