I have had problems with my Ruger Mark II, it likes to be cleaned every once in a while, but it's a finicky semi-auto, not a revolver.
Ive always had problems with 22's when they get dirty, but for me, the revolvers seem to have more light strikes or failures to fire on the first strike, than the autos. The rounds almost always fire on the second strike if you just keep cycling through, which I think shows a compromised first strike. I dont realign the round for another try.
Dont usually have the light strike problems with the autos though, and its been more of a cycling thing, especially with certain guns there as they get dirty. The worst guns Ive had with that were the Beretta 21A's I had. Clean, they usually worked great, but that quickly degrades as you shoot and the guns get dirty.
I think the issue with the revolvers is the chambers get dirty, and if you arent paying attention, and fully seating the rounds as you load, it deadens the hammer strike when the hammer has to finish fully seating the round. I have a S&W 63 and had a 317, and both seemed to always have the problem as the guns got dirty.
I clean after every outing, and early on, theres no trouble, but as you get past a hundred rounds or so, they start having misfires every cylinder, "if" you dont take the time to make sure the rounds are fully seated. When you load, they may look like they are fully chambered, and the cylinder will easily close, but if you firmly push on the rounds, a lot of times, they will seat that little bit more, and are then fully seated.
The autos usually dont have that problem, as the weight of the slide usually gets them fully chambered without trouble.
Ive owned quite a few 22 autos over the years, from cheap Rugers and High Standards to fairly expensive Brownings and Smiths, and all of them seemed to have issues if they weren't kept clean. Most usually choked in some fashion after a couple of hundred rounds. The exception to that has been a couple of Glock 44's I picked up recently. They are the only 22 autos I currently have, and they will run a full brick with no troubles at all.
In fact, they are into their fourth case now between them, and have only had three stoppages in over 15K rounds. The only reason I was keeping track, was because I was told early on, they were junk, jam o matics, and wouldnt make it through a mag without problems. They have been the most trouble free 22 auto's Ive ownd so far.
I clean and lube everything I shoot, every time I shoot it, one round or a couple of thousand, doesnt matter. Im always amazed when I hear some say they never clean and never have issues or problems. Just seems incredulous to me. In 60 some odd years of shooting now, that has never been my experience, single shots to full autos. Cleaning and maintaining your guns is just part of keeping them up to par and ready to go.