I have shot a couple of deer with the 200gr XTP from a S&W 1006. This was back in the early 90's before the 10mm was down loaded to accomodate the Glock Mod20.
My load is a now above max load of Acc#7, but was safe and accurate from MY S&W. It was a published max load circa 1992.
MV was about 1,200fps from 5" bbl of Mod 1006.
It performed perfectly. 3" exit wound on lung shot deer. Deer died quickly. Effect was similar to that from a .30/30 with 150gr bullets at rock-throwing distances.
For Self Defense, this load will work, and a load you use for "hunting" purposes is easier to defend against than something intended for "harm and death" to a human. (I was never tried in court, but had co-workers who were.)
In a criminal proceeding, the question will be "were you justified in using deadly force"....... right, or wrong....
In a "civil proceeding", the question was did you intend to cause suffering and harm, beyond that permitted by legal justification, and did you use force that was intended to be excessive or brutal resulting in grievous injury or harm.......
Co-worker was carrying "dept. issue 158gr Winchester Lead Semi-wadcutter .357mag ammo. Shot to pre-orbital arch of the forhead of a subject pointing a 12ga Rem. 1100 loaded with 3" mag buckshot, completely penetrated the cranium and exited leaving a 2" exit wound.
Co-worker was exonerated by both criminal and civil proceedings. It helped that the subject had a history of mental illness and criminal assaults.... and had threatened to "kill any game-warden" he ran across.....
Better to be tried by 12 than carried by 6.
Personally, I'd go with a 155gr "self defense" load as recoil is somewhat less than the near .41mag level of the 200gr 10mm load.
The reason is muzzle control and recovery for follow-up shots.
This is the reason for the creation of, and popularity of the .40S&W.
fwiw; When I was still working, I was issued a Glock M22. I could carry any factory loaded ammunition. I chose to carry the 155gr Winchester Silver-Tip rather than the issued Ranger SXT 180gr load. It had the highest m/v of any 155gr load available at the time (1,220fps chrono'd from my 4-5/8"bbl. M22), and penetration was adequate to completely penetrate the chest cavity of a 140lb deer with a broadside hit. Accuracy was excellent too.