Hi,
You don't need a jacked up .45LC hunting round to plant a deer. Also, it can be hard to find.
OTOH, there are a lot of dedicated hunting rounds out there for the .44 Magnum, and the .44 will do the job extraordinarily well with good shot placement.
I agree you don't need a scope. However, I believe very strongly in the benefits of a quality red dot scope. From years of handgun competitions I've come to really appreciate their incredibly fast target acquisition times. With scopes you sometimes can't swing the gun and find the sweet spot easily . . . and with iron sights (where sight alignment perfection is so key) it is hard to keep the eye focused on the front sight with a blurry deer at a distance and also be able to notice limbs and twigs in the way that can spoil your bullet's path.
My favorites are the Holosights. I'm a deer hunter that hunts with a .44 Mag handgun and I have now for many, many years. I started with an iron-sighted 3-screw Ruger Super Blackhawk, moved on to an early Thompson Center Contender in .44 Magnum, and have been using a S&W Model 29-5 for the past decade or so.
BTW, the hide beneath the gun is from a rare Piebald Whitetail Buck. I took it in extremely thick cover at 35 yards. As he was working his way quickly past me during the rut, I could see the rack but not the body!
Finally, he passed through an area where the shoulder and heart area would pass behind a slight break in the vegetation of about eight inches or so. I could NOT have tracked him with a scope and seen the opening probably, and iron sights would have made it difficult too. You see . . .
The Holosights let you keep both eyes open and looking at the deer as it moves through the thick woods. The red dot seems to magically look like it is painted on the deer, and your eyes are freed to look for the right spot in the understory to squeeze a round through an narrow break in vegetation and bring your deer down humanely.
Effectiveness?
Twice now I've dropped THREE in mere seconds, once in a fresh clearcut on a ridge, and the second time in a thick, hardwood bottom. The first time, the second deer took off when the first one went down and was running full speed, BROADSIDE (luckily) at a measured 65 yards. I swung the Holosight and had a perfect sight picture when I touched off the round. The deer hit the ground like a stone RIGHT THERE, and never twitched! The a third deer stood up (it was bedded in the clearcut and I didn't know it) so I dropped it too. Ah the memories!!!
This past season, I took my best to-date Whitetail buck (an eight-point) with my gun and sight. The bullet took the heart out and he never pumped another beat.
Holosights are used today in combat and by law enforcement against targets that won't stand still, and they are incredible in their effectiveness. My AR15 also is topped by a quick-pointing Holosight! Bottom line . . .
I DO NOT LIKE TO TRACK DEER . . . AND I want instant kills, and the Holosight has made all the difference in the world in not having to track downed deer!