My response is conditional - I live in a house with no children present, only myself and my wife. My house is alarmed, but that is normally set only when we are out of town. We have a 105-pound Rhodesian Ridgeback who follows my wife from room-to-room all day and all night. I keep a non-sentimentally-attached handgun in my nightstand with a Surefire and an extra magazine (if somebody stole it, I would be annoyed, but nothing more - current manufacture, easily replaced). I will not try to "clear" my residence if I awake and hear somebody/something at the other end of the house. I will take that bedside gun, assume a defensive position (or leave the house via the bedroom's exterior door) and call the police (my cell phone resides on the nightstand too, it's where I put the charger - there's a land line there too). Behind my bedroom, farther from the rest of the house, is a combination laundry room and closet. In the closet is a second handgun on the back of the wall above the door (you would have to lean in and look up). It too is of no sentimental value.
My "good stuff" lives in a safe. The safe is installed inside a cabinet built in to a powder room (a half-bath off the hall). The doors on the cabinet are flush with the wall, painted with wall paint - if you just glance into the bathroom, you don't see them. The safe's bolted to the slab on which the house is built, so you would have to open it in place, blow it open or tear out about ten feet of interior partition and then open it somehow. As somebody noted, the most likely burglar is guy with bad teeth, sores on his arms and a meth habit, so he will have to settle for grabbing the four-year-old laptop on the desk and the TV. If he comes in my bedroom door, while he wrestles with the Ridgeback, I'll probably see if the Mozambique drill works. If he stays in the other end of the house, I'll see how the local police clear a house.
What am I missing here? The Government probably isn't coming for my guns without some serious changes in the law or some natural disaster and even then, I don't think it's likely. A tweaker is what I really have to defend against and they're not really very bright in the first place.
