I bought a P2000sk .40-LEM about two months ago. This goes with my USP45 fullsize that I got last year. They're for different purposes, with the SK for carry use and the 45 as home defense, plus range use. The biggest difference is the SK's LEM trigger which negates the need for a safety lever, something to NOT need to remember in an emergency. The first shot I ever took with the SK, after firing the USP a bit, I honestly thought there was something wrong with the SK. The trigger pull is significantly longer than the USP's which isn't a LEM. But that was by comparison to the USP. It is just VERY different.
After a few hundred rounds, I'm very comfortable shooting each type on a range day. I train with the SK differently than I do with the USP. Considering the use in a worst-case scenario, I don't expect to have the time to sight as much as I would want. And, I don't shoot the SK at 25 yards as much as I do at 7 yards. Being able to point-and-shoot at the closer range is more important with the SK as a carry gun. In that light, it's extremely capable.
Fast follow-up shots on target just happen now, without using the sights to acquire the target. In fact, my brother had a heck of a time using the sights. When I suggested bringing the target in to about 7 yards and just pointing, he promptly put three rapid fire into center torso in a group about the size of a baseball! Before that, he was really unsure if he was going to be happy with the SK. Now, he's also very comfortable knowing that he can put it on target without having to think about it.