I have read some things in magazine articles and other BP forums about how they are a touch lighter in igniting the powder and lends to better accuracy. But like I said, I want to hear from people with personal experiences. While I am not saying I don't trust the authors of credible magazines, I still think it is better to hear from many that had been there and done it for themselves.
A few months ago I purchased a Pedersoli heavy barrel Sharps in 45/70. Due to a lack of large rifle primers I use Federal Large Pistol primers of which I have a generous supply.
Loading 65 grains of 2F under a 405 grain bullet. Using a drop tube then a compression die, the bullet is just touching the powder surface when seated.
I’m only 100 rounds into shooting this rifle and so far there has been no indication that the primers are failing in any aspect. Not flattened, the firing pin isn’t punching thru and no leakage.
Using the drop tube I can get the full 70 grains in the case then use the compression die to avoid compressing the powder with the bullet. I’m still in the process of finding the best powder charge for accuracy with the full effect of this big rifle.
My only point here is I haven't experienced any safety issues using the pistol primers.
I can’t speak to any other aspect as I’ve never shot any other load thru this big rifle. BP, even at these higher charge loads are tens of thousands of psi below smokeless loads. I’d advocate a cautious approach using pistol primers if I were to move in that direction.
Also powder Inc has large rifle primers at $98 a k, one per person, I bit the bullet and ordered a brick so for now the large pistol primers will be reserved for the 44 and 45 pistol loads.