I do 45ACP and .223 Remington (as of today) on my Pro 1000. When changing powder charges, or starting loading for the day, I run 5 charges through and just dump them back into the hopper. After that, I measure the next 3 charges to verify that it's throwing consistent charges. Every so often, I'll take a round out and measure the charge, to make sure they're still consistent. I've run BL-C(2) and Unique through mine with no troubles whatsoever.Like the others have said, make sure your primer feed setup is CLEAN. Since I have 2 trays, I make a point to keep both loaded when I am doing bulk 45acp so I can swap when the first runs dry.
As for the .223, I have only loaded 25 so far, and I'm already tempted to buy a single stage and universal depriming die. Its a PITA to deprime/resize all the brass like a single stage, following up with trimming and deburring. After its all done, I run it through like a progressive. It took me quite awhile to do 25 tonight, because I did 5 ea of varying powder charges from 23g to 26.5g of BL-C(2). It'll go faster when I get a load the AR likes.
Anyhow, yes, I like my Pro1000. It has served me well for ~2yrs now, with not a single problem to date!