Actually, Hodgdon's Lil'Gun, was developed for the .410 Shotgun, but as it turns out, is the all time best powder for the .22Hornet.
My "pet" load for the .22Hornet is the 40gr Sierra Varminter HP, seated to 1.780" over 12.5gr of Hodgdon's Lil'Gun; a Winchester SmallPistol primer and NeckTurned brass cases. Gives 3,000fps and submoa accuracy. However, for 50gr Hornady "blitz", try Accurate #1680 at 10.8gr for 2,470fps but "one-hole" accruacy. For the 35gr and 33gr V-max, try H110 at 11.2gr for 3,100fps.
Don't have a .280 but would suggest the Nosler 140gr Ballistic Tip bullet and IMR4350. 46.5gr of IMR4350 and the 140gr Ballistic Tip gives 2,800fps and sub-moa accuracy in my Rem M7 in 7mm-08. The Sierra 140gr Game King and Pro-Hunter are very good too. Almost as good of accuracy with superior game performance is the 140gr Remington CorLokt. In my experience,the CorLokt will out-perform the 140gr Nosler Partition. Go figure !, cheapest bullet is a better game bullet than nearly the most expensive.............
For the .30/06, Best accuracy is with either a Sierra 150gr or Nosler 150gr Ballistic Tip over 52.0gr of IMR4064. Better velocity can be had with 53.0gr of RL-15 but not as good of accuracy. (3,000fps). Accuracy is astonding with a 165gr or 168gr with 56.5gr of IMR4350. (H4350 is "faster" but not as accurate). With the 180gr bullet, either a Sierra, Speer, Flat-Base over 60.0gr of RL-22 for at or just under 2,800fps. A real accurate "power-house" load.
For the .45/70, I use a RCBS 300gr FNGC (mine casts to 318gr w/gas-check) over either 48.0gr of H4198 or 53.0gr of IMR3031 for 1,900fps from Marlin 1895 GuideGun, or 2,000fps from 22" bbl. Mine shoots to near MOA and kills deer like lightning.
I've not fooled around with the .44mag in over 20yrs. I've loaded a few rounds for aquaintances.
With the 240gr and lighter jacketed bullets, I've had best luck with H110 and #2400. With cast bullets, #2400 and Unique. I've shot a LOT of 10.0gr of Unique under a 255gr Keith-style SWC for around 1,100fps. And of course 22.0gr of #2400 for ~1,400fps. BE CAREFUL WITH THIS DATA AS IT'S OVER 20YRS OLD.