anything .45acp for a handgun. Good chance intruders could be hopped up on drugs. .45acp has the knockdown to lay them on their ass, and allow you to at least stand a chance. Inner city? .44 mag or larger.
but Primary weapon would be a HD 12ga.
Since I only have a pretty sporting 12ga, Id grab my 1911, or if time was an issue, my Kel-Tec P-11 is always chambered with a full mag (11 rounds total). And, its on my nightstand or on my person.
and the 12ga better be a pump. The sound of a 12 ga pump racking (hard and fast) should scare away any intruder that values life. I racked my shotgun (empty) one day and my brother about messed himself. He agreed anyone hearing that would run....