I have been present inside a rather small room when a 145-grain Winchester Silvertip was touched off in a 4" sixgun. Pictures remained on walls, and while my ears were not happy, I could still hear. I was not in fight-or-flight mode when that round went off, so that was not why my ears were not deafened. I was also present in a small room when a .45 ACP Silvertip was fired from an N-frame snubby. The experience was not as bad as the .357 discharge, and pictures remained on the walls. Knick-knacks were not present on shelves in either case; perhaps those would have indeed been knocked about.
hags linked to a Gunblast.com article by R.K. Cambell, which I have read before, and I agree. The .357 is an excellent defensive round, for sure, and I have used it with good effect, from my point of view. No, not the above-mentioned Silvertip in a small room, but a 125-grain Federal JHP in a parking lot. I don't need Marshall/Sanow to tell me the .357 is excellent, and I still use it regularly for HD, carry, and police back-up. If I had to stick with one cartridge for all reasons and seasons, it would be the .357 mag.
So, why did I go with .45 in the poll? Well, HD was the specified parameter. I love the .357 for the streets and for field use, but for home defense, if I can't have a long weapon in my hands, I want a large autopistol. My SIG .40 duty pistols are excellent, but .40 was not a choice. My .45 Les Baer TRS is excellent, too, and .45 was a choice.
To get really picky and long-winded, I will add that if I do have a long-barreled firearm in my hands, and am in HD mode, I consider spurless-hammer .357 sixguns to be excellent backups to the long weapon.