Reloading 45-70

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I would assume so, black powder and lead started it all, and these are just coated lead.
 
If you are using traditionally lubed bullets, make sure they have black powder lube if you are shooting black powder.
 
Another thing is I would like to mention, whether it is black powder or smokeless make sure that you keep the velocity of your reloads under 1500 fps, above that I would consider using a gas check.
 
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