Yes, it is in fact chambered in .22 Remington Automatic.
This is not the same caliber as .22 Long Rifle.
The Model 16 was the first semi-auto .22 made by Remington in 1914.
At the time most .22 ammo was loaded with black powder or semi-smokeless powder, and black powder fouling and semi-auto's do not co-exist well together.
Winchester did the same thing when they introduced their first semi-auto in 1903. Their cartridge was called the .22 Winchester Automatic.
Both the Rem & Win .22 Automatic ammo was loaded with smokeless powder, and they were both invented to keep black powder .22 ammo from being used the new fangled semi-auto rifles.
Today, both Remington & Winchester .22 Automatic ammo are collectors items, and priced as such. It hasn't been made since World War II.
BTW: The .22 Remington Special is the same thing as Winchester .22 WRF.
It was for Remington and Winchester pump rifles of the day.
It is still being loaded by CCI, and Winchester on occasion.
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