I don't know where all these "unreliable" 22LR loads are, but I've never come across any of them.
I must have gotten all the misfires the ammo makers intended for you.
It depends on ammo. Fed bulk pack seems to have at least a couple of duds per pack in most of my guns. My Rossi revolver and my NAA mini revolver in the caliber do well with it. It's also GUN dependent and .22 ammo does not age well, especially in humid environments, especially in a sweaty pocket in a humid environment. I change carry ammo weekly in my little NAA back up.
The LCR might be better for snake country and all because it will fire repeated rounds of snake-shot without manually cycling, but it doesn't sound like that's gonna be your primary purpose for the gun. The LCR may also be better for breaking in new shooters.
I have shot snakes. Other than the ones I've shot with a shotgun, I never shot 'em with a shot load, just a bullet. I've killed lots of shakes with a .22 caliber bullet. I've hit 'em as far away as 25 yards with a bullet shooting snakes on a farm tank (a favorite past time in years past), so a head shot at 15 feet is nothing. I've done that with my mini revolver before. If you can shoot a handgun, you don't need to carry shot loads.
But, I don't shoot rattlers that I don't want to eat, don't kill them unless they're in my yard. In the yard, a garden hoe will keep you from being arrested. Out on my place, hey, one dead snake out of 10,000? Not worth the waste of ammo, won't make a dent in the population and it ain't like they're going to hunt you down and eat you like a polar bear or something. My BEST defense against snakes is snake boots, about 70 bucks at Academy and they're waterproof, to boot. They're known as "south Texas Ropers" around these parts.
Mine have paid for themselves. I never saw the snake so a gun would have been worthless to me. The ER bills alone would have been WAY more than those snake boots and it's 45 minutes to town.