I have a Ruger Speed Six.
When I started carrying it, I played around with speed loaders.
It was a fumble-fest. I had to align the bullets perfectly with the holes in the cylinder, or they just would not go in.
After fiddling around with it for a while, I gave up on it.
Then, later on, I got tired of the hammer chewing on me where it's knurled on top. It would rub the hide right off me. The edges of the hammer were like a sawblade.
So, I started "De-Horning" the pistol.
I worked it over, and rounded the many sharp 90 degree edges on the pistol and dulled all the sharp edges it had.
And it was during this process that I noticed the rear edge of the chambers.
They were a sharp 90 degree edge. Hmmm...
So, I took a bullet and watched carefully as I inserted it into the chamber.
Yep, no doubt about it- that sharp edge was digging into the soft bullet and making it difficult to put the bullet in.
I gently applied a small bevel to the rear edge of the chamber, and to the ejector star, so it was nice and smooth all the way around.
I'm not talking about a big funnel on the chamber, just a very small bevel maybe 30 thousandths across.
I did it by hand with a small round file and some emery paper and then blended it to the pistol's finish with a fine scotch brite pad.
After that, rounds just drop into the chamber.
Loading is FAR easier now, and the speedloader is much simpler to use. (But I prefer the Speed Strips)
I know that somebody is going to say the case is going to blow out where I removed support but the pistol has been fired a lot since then and the cases show no sign of stress around the head.
Take a look at your pistol. If your chambers have a sharp edge you might want to think about a little bevel action there.
It sure made mine handle better.