Tamara:
I can too, but I've seen S&W 25's (by whatever number) hang up because of a bent or twisted clip. Also headspacing on the front of a cartridge case can be imprecise in a revolver. Given all of the possibilities, even if they are not probabilities, I perfer rimmed cartridges in a revolver (after all, they were made in the first place for revolvers) rather then cartridges that were originally intended to be used in pistols. A speed loader may or may not be as quick too use as a full-moon clip set-up, but I think the difference isn't consequental. If a person thinks this is important they might better be looking at automatic pistols.
As I pointed out to "Nightcrawler," the choice of any handgun (or any firearm for that matter) should be based on what the user intends to use it for. If Nightcrawler is looking for a defensive arm he should consider the .45 ACP models - both from their strong and weak points. I don't think he's looking for a revolver to use in combat style match shooting. If he was (or I was) I'd consider the "clipped-cartridge" revolvers. If this is to be a "range and field" gun I'd go for one of the rimmed magnum cartridges.
In any case the choice is his to make, based on the different points of view he receives.