Seems like every time someone asks for "the best", I find out that their definition of best and mine differ greatly. Sometimes folks say money is no object then they want one under $400. So I must ask, best for what purpose and in what price range?
Ditto!!
For a currently available semi auto plinker &/or up to Master Class Bullseye competition, Ruger MKII 5 1/2" with a replacement Volquartsen sear, Ultra Dot (if so inclined), and skateboard tape on the frontstrap and bottom of the heel. I have yet to own one (now have 5) that doesn't shoot under 1 1/2" @ 50 yards with good target ammo. Now add to that about 3-4 CASES of CCI Standard Velocity ammo and go shoot.
If a revolver is your preference, I'd definitely agree with the S&W for any serious work and a Ruger Single Six for rough knock around usage.
I know there are a few well made European target pistols, but without knowing your end result goals I would hesitate to recommend going that route. As was also mentioned the S&W 41 is a very well made target grade 22 as well as the High Standard. But both of those may be a bit harder to try out, depending on your location.