I've seen shooters with handguns, leveraction rifles attempt to fire multiple rounds with the safety still engaged. With the rifles they keep cycling the lever and pulling the trigger until finally they hear someone yell, "safety, safety" and they finally disengage it after cycling multiple live rounds out of the gun.
But these are typically shooters who have difficulty with every phase of shooting. Slow, not accurate, poor gun handling, everything. If it's difficult for a shooter to use a gun with a manual thumb safety, don't use one.