Early-on, I made some questionable choices in cartridges, starting with a .30-06 which I used to hunt varmints, then sold that fantastic rifle to afford a .22-250 Rem 700 ADL as my only centerfire. I won lots of turkeys with it and took lots of varmints, even a deer or two, but it was a little too light for deer beyond 200 yards. I eventually went to .270 Win for deer and .243 Win for varmints (both hand-loaded)...and that's where things lie today, except that I spend more time and money hunting/shooting with the .17 HMR...a really fun round for "sub 200 yard" varmints, even managing to bag a few coyotes with it.